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Paving the Way forStem Cell Therapies

Scale Your Cell Culture Up to 100 Billion Cells per Batch

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How We Empower Your Success

At CytoNiche, we understand the complexities of cell and gene therapy manufacturing, especially when the drug is "alive". That's why we offer a revolutionary approach to large-scale cell culture manufacturing that addresses the key challenges of scalability, cost-efficiency, and product quality. Our cutting-edge 3D FloTrix technology is transforming the production of adherent cells, enabling you to achieve industrial-scale cell yields with unprecedented efficiency. Backed by extensive industry experience, this core technology is not only utilized in several upcoming registered clinical trials but also in a commercialised therapeutic product.

Whether you're working with mesenchymal stem cells (MSCs), exosomes, or other emerging adherent cell-based technologies, our systems allow for the production of billions of high-quality cells in a fraction of the time and cost of traditional methods. With a focus on reducing facility footprint, labour costs, and contamination risks, our technology supports a new era of sustainable biomanufacturing.

Up to

90 %

Less Footprint

Up to

80 %

Less Manpower

Up to

50 %

Less Time

Up to

30 %

Less Reagents

The Science
Behind the Innovation

We've revolutionised cell culture manufacturing with our dissolvable porous microcarriers that are a game-changing solution for applications such as stem cell therapies, vaccines, and exosomes.

Our microcarriers, supported by Type II and Type IV FDA Master Files, are made from a safe, widely available biomaterial and are designed to address major manufacturing challenges. Unlike traditional methods, these microcarriers dissolve gently under controlled conditions, ensuring nearly 100% cell recovery and minimising residual material. This results in higher cell viability, simplified harvesting , and reduced contamination risk.

The porous structure provides a high surface area-to-volume ratio, enabling more cells to grow in the same bioreactor volume. This boosts productivity while lowering costs, labor, and space requirements. By integrating these microcarriers with our 3D FloTrix Technology, we've created fully automated, closed bioreactor systems that streamline the entire process from culture to harvest.

Our innovations empower your team to scale with confidence, maintain regulatory compliance, and optimize manufacturing workflows. With CytoNiche, you can advance the commercialisation of cell therapies, vaccine production, and even emerging technologies like cultivated meat. Discover how we are helping industry leaders accelerate time to market and achieve improved therapeutic outcomes.

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Revolutionising Stem Cell Manufacturing

Unlock the future of mesenchymal stem cell (MSC) production with CytoNiche’s 3D FloTrix™ Technology—a game-changer for scalability, consistency, and cost-efficiency.

Scale-up Cell Culture

Cell Processing & Filling

Revolutionizing Stem Cell Manufacturing with 3D FloTrix™

Key Benefits

Mass Production Simplified

Dissolvable microcarriers enable effortless production of billions of high-quality MSCs in a single batch, eliminating adaptation to suspension culture and delivering harvest efficiencies of nearly 100%.

Unmatched Consistency

Every batch meets or exceeds industry standards, making the system suitable for efficient and scalable manufacturing.

Closed-System Safety

Fully automated, contamination-free workflows preserve cell integrity while real-time monitoring provides precise control over growth parameters.

Proven Commercial Success

Backed by FDA Master Files and cGMP-compliant microcarriers, media, and equipment, our technology has accelerated the commercialisation of FDA-approved stem cell therapies.

Cost-Efficient Scale-Up

Reduce labor, facility, and reagent costs through streamlined automation, optimised space utilization, reduced manual operations.

Why Partner with Us?

From seed train cultivation to fill-and-finish, 3D FloTrix™ supports end-to-end large-scale manufacturing. Its industry-proven design has already been adopted for ongoing and planned clinical trials. Experience smarter scalability - explore how 3D FloTrix™ can accelerate your MSC pipeline.

Tailored Solutions for Exosome Challenges

Harness the power of MSC-derived exosomes—nature’s precision therapeutic vehicles—with CytoNiche’s 3D FloTrix™ Technology, designed to overcome scalability and yield challenges in exosome production.

Separation & Concentration

Filling

Cell Bank Expansion

Automated Exosome Harvest

3D FloTrix™ Route for Harvest and Concentration for Exosomes

Why MSC Exosomes?

Balanced Therapeutic Profile

MSC-derived exosomes deliver regenerative, anti-inflammatory , and immunomodulatory benefits with a favorable safety profile compared to cell-based therapies.

Regulatory Readiness

MSC-derived exosomes are being actively investigated in clinical studies, supported by their low immunogenicity and emerging safety data.

How 3D FloTrix™ Elevates Exosome Manufacturing?

High-Yield MSC Factories

Scale MSC expansion to create powerful exosome-producing cell factories within a closed, cGMP-aligned system.

End-to-End Integration

Seamlessly transition from MSC expansion to exosome isolation,reducing process complexity and contamination risk through a closed , integrated workflow.

Efficient Exosome Harvesting

Enhance exosome yield and purity by leveraging MSCs expanded in 3D FloTrix™ bioreactors, combined with optimised feeding strategies, exosome-depleted, serum-free media, and scalable harvesting systems—supporting consistent exosome recovery from culture supernatant.

Why it Matters?

Exosomes derived from 3D FloTrix™-cultured MSCs retain their bioactive cargo (proteins, miRNAs, lipids) and functional potency, making them ideal for applications in regenerative medicine, cancer therapy, and precision drug delivery. Discover how 3D FloTrix™ solves your exosome production challenges—click to learn more!

Integration for Optimised Biologic Production

The surge in demand for advanced viral biologics—from oncolytic viruses to next-generation vaccines—has exposed critical bottlenecks in traditional manufacturing. Adherent cell culture, the backbone of viral production, remains constrained by scalability limitations, inconsistent yields, and complex downstream purification. At CytoNiche, we redefine what’s possible with 3D TableTrix™ Microcarriers (V Series and G Series)—a breakthrough engineered to transform adherent cell workflows into scalable, high-yield bioreactor processes.

Why Settle for Legacy Limitations?

Traditional microcarriers force cells into cramped 2D growth on rigid surfaces, where aggressive bioreactor stirring compromises viability and generates hazardous fragments. For some difficult strains, they may not grow, or produce viruses when on 2D rigid spheres. These inefficiencies cascade into inflated costs, safety risks, and subpar virus titers.

The CytoNiche Advantage

3D Dissolvable Design

Our porous microcarriers mimic natural tissue architecture, enabling adherent cell lines such as Vero (the gold standard for polio, rabies, and COVID-19 vaccine production), MDCK, diploid cells (MRC-5, SV-1), and HEK293T to thrive in a 3D environment. Achieve high cell densities of up to 1 × 10⁷ cells/mL—ideal for efficient scale-up.

Fragment-Free Harvest

Scale up using intact beads (bead-to-bead transfer) or dissolve microcarriers post-culture to harvest cells for the next stage. This approach minimises debris, improving downstream processing efficiency and reducing contamination and safety risk.

Enhanced Viral Harvest

Outperform 2D flasks and traditional microcarriers with consistently elevated yields of up to 100x higher titers for common vaccines, lenti-viruses, adeno-associated viruses or oncolytic viruses.

Built for Tomorrow’s Challenges

From multistage bioreactor amplification to cGMP-ready processes, 3D TableTrix™ empowers agile responses to emerging threats. Whether producing viral vectors, oncolytic therapies, or pandemic-ready vaccines, our platform ensures faster timelines, lower costs, and uncompromised quality.

Unlock Scalable Production

Move beyond the limitations of legacy systems. Discover how CytoNiche’s integrated solutions enable scalable, high-titer production of viral biologics—one batch at a time.

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