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Paving the Way forStem Cell Therapies

Scale Your Cell Culture Up to 100 Billion Cells per Batch

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How We Empower Your Success

At CytoNiche, we understand the complexities of cell and gene therapy manufacturing, especially when the drug is "alive". That's why we offer a revolutionary approach to large-scale cell culture manufacturing that addresses the key challenges of scalability, cost-efficiency, and product quality. Our cutting-edge 3D FloTrix technology are transforming the production of adherent cells, enabling you to achieve industrial-scale cell yields with unprecedented efficiency. Backed by extensive industry experience, this core technology is not only utilized in several upcoming registered clinical trials but also in a successfully commercialized therapeutic.

Whether you're working with mesenchymal stem cells (MSCs), exosomes, or other future technology based on adherent cells, our systems allow for the production of billions of high-quality cells in a fraction of the time and cost of traditional methods. With a focus on reducing facility footprint, labor costs, and contamination risks, our technology supports a new era of sustainable biomanufacturing.

Up to

90 %

Less Footprint

Up to

80 %

Less Manpower

Up to

50 %

Less Time

Up to

30 %

Less Reagents

The Science
Behind the Innovation

We've revolutionized cell culture manufacturing with our dissolvable porous microcarriers a game-changing solution for scalable production of adherent cells, critical for therapies like stem cells, vaccines, and exosomes.

Our microcarriers, supported by Type II and Type IV FDA Master Files, are made from a safe, widely available biomaterial and are designed to address major manufacturing challenges. Unlike traditional methods, these microcarriers dissolve gently under controlled conditions, ensuring nearly 100% cell recovery and minimizing residual material. This results in higher cell viability and simplified harvesting, reducing contamination risks.

The porous structure provides a vast surface area, enabling more cells to grow in the same bioreactor volume. This boosts productivity while lowering costs, labor, and space requirements. By integrating these microcarriers with our 3D FloTrix Technology, we've created fully automated, closed bioreactor systems that streamline the entire process from culture to harvest.

Our innovations empower your team to scale with confidence, maintain regulatory compliance, and optimize manufacturing workflows. With CytoNiche, you can drive forward the commercialization of cell therapies, vaccine production, and even emerging technologies like cell-cultured meat. Discover how we are helping industry leaders accelerate time to market and achieve better therapeutic outcomes.

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Revolutionizing Stem Cell Manufacturing

Unlock the future of mesenchymal stem cell (MSC) production with CytoNiche’s 3D FloTrix™ Technology—a game-changer for scalability, consistency, and cost-efficiency.

Wash and concentration

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Scale-up Cell Culture

Cell Processing & Filling

Revolutionizing Stem Cell Manufacturing with 3D FloTrix™

Key Benefits

Mass Production Simplified

Dissolvable microcarriers enable effortless production of billions of high-quality MSCs in a single batch, eliminating adaptation to suspension culture and delivering harvest efficiencies of nearly 100%.

Unmatched Consistency

Every batch meets or exceeds industry standards, ensuring reliable cell quality for research and therapeutics.

Closed-Sysiem Safety

Fully automated, contamination-free workflows preserve cell integrity while real-time monitoring provides precise control over growth parameters.

Proven Commercial Success

Backed by FDA Master Files and cGMP-compliant microcarriers, media, and equipment, our technology has accelerated the commercialization of FDA-approved stem cell therapies.

Cost-Efficient Scale-Up

Reduce labor, facility, and reagent costs through streamlined automation, optimized space utilization, and minimized manual operations.

Why Partner with Us?

From seed train cultivation to fill-and-finish, 3D FloTrix™ supports end-to-end large-scale manufacturing. Its industry-proven design has already been adopted for multiple active and planned clinical trials. Experience smarter scalability - explore how 3D FloTrix™ can fast-track your MSC pipeline.

Tailored Solutions for Exosome Challenges

Harness the power of MSC-derived exosomes—nature’s precision therapeutic vehicles—with CytoNiche’s 3D FloTrix™ Technology, designed to overcome scalability and yield hurdles in exosome production.

Separation and concentration

Filling

Cell bank expansion

Automated exosome harvest

3D FloTrix™ Route for Harvest and Concentration for Exosomes

Why MSC Exosomes?

Balanced Therapeutic Profile

MSC exosomes deliver regenerative, anti-inflammatory, and immunomodulatory benefits without the risks of cell-based therapies.

Regulatory Readiness

Clinically preferred for their safety, low immunogenicity, and growing acceptance in trials.

How 3D FloTrix™ Elevates Exosome Manufacturing?

High-Yield MSC Factories

Produce large-scale, cGMP-grade MSCs—the living "cell factories" for exosomes—using the same scalable, closed-system technology trusted for stem cell manufacturing.

Efficient Exosome Harvesting

Optimize yield and purity by leveraging MSCs grown in 3D FloTrix™ bioreactors, repeated batch feed process, exosome-free serum-free medium and large-scale harvesting system, ensuring consistent exosome production from culture supernatant.

End-to-End Integration

Seamlessly transition from MSC expansion to exosome isolation, reducing process complexity and contamination risks.

Why it Matters?

Exosomes derived from 3D FloTrix™-cultured MSCs retain their bioactive cargo (proteins, miRNAs, lipids) and functional potency, making them ideal for applications in regenerative medicine, cancer therapy, and precision drug delivery. Discover how 3D FloTrix™ solves your exosome production challenges—click to learn more!

Integration for Optimized Biologic Production

The surge in demand for advanced viral biologics—from oncolytic viruses to next-gen vaccines—has exposed critical bottlenecks in traditional manufacturing. Adherent cell culture, the backbone of viral production, remains shackled by scalability challenges, inconsistent yields, and costly purification hurdles. At CytoNiche, we redefine what’s possible with 3D TableTrix™ Microcarriers (V Series and G Series)—a breakthrough engineered to transform adherent cell workflows into scalable, high-yield bioreactor processes.

Why Settle for Legacy Limitations?

Traditional microcarriers force cells into cramped 2D growth on rigid surfaces, where aggressive bioreactor stirring compromises viability and generates hazardous fragments. For some difficult strains, they may not grow, or produce viruses when on 2D rigid spheres. These inefficiencies cascade into inflated costs, safety risks, and subpar virus titers.

The CytoNiche Advantage

3D Dissolvable Design

Our porous microcarriers mimic natural tissue architecture, enabling adherent cells like Vero (the gold standard for polio, rabies, and COVID-19 vaccines), MDCK, diploid cells (MRC-5, SV-1) and HEK293T to thrive in 3D. Achieve peak densities of 1×10^7 cells/mL—ideal for seamless scale-up.

Fragment-Free Harvest

Choose to scale-up with beads intact (bead-to-bead transfer) or dissolve and harvest cells for the next stage. Microcarriers dissolve post-culture, eliminating debris that clogs downstream purification and slashing safety risks.

Superior Viral Output

Outperform 2D flasks and traditional microcarriers with consistently elevated yields of up to 100x higher titers for common vaccines, lenti-viruses, adeno-associated viruses or oncolytic viruses.

Built for Tomorrow's Challenges

From multistage bioreactor amplification to cGMP-ready processes, 3D TableTrix™ empowers agile responses to emerging threats. Whether producing viral vectors, oncolytic therapies, or pandemic-ready vaccines, our platform ensures faster timelines, lower costs, and uncompromised quality.

Unlock Scalable Precision

Step beyond the limits of legacy systems. Discover how CytoNiche’s integrated solutions are accelerating the future of viral biologics—one high-titer batch at a time.

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