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3D FloTrix™ vivaFILL Cryovial Filling System

A highly efficient automated system that decaps, fills and recaps up to nearly thousand cryotubes of live cells and exosomes in an hour.

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Overview

The 3D FloTrix™ vivaFILL Cryovial Filling System provides the definitive solution to the critical challenges of modern cell therapy manufacturing: enabling high-volume throughput, ensuring robust intra-batch quality control, and streamlining complex operational workflows. Engineered for superior consistency, stability, and repeatability, it ensures flawless execution for both master cell banking and final product fill-finish processes, all while adhering to the most rigorous industry compliance standards. Precision-engineered, economically optimised, and performance-driven, vivaFILL establishes a new benchmark for excellence in automated cryovial filling.

Applications

● Master and Working Cell Bank (MCB/WCB) preparation
● Strain Preservation and Banking
● Aliquoting & Packaging of Critical Reagents or Bulk Drug Substances
● Controlled-volume Dispensing in QC, R&D, and Production Setting

Product Features

● Synchronised decapping and recapping of 16 vials per cycle via laser-guided alignment
● High preservation of cell viability (>95%) with low-shear design
● Supports 8-channel filling per cycle with volume consistency within ≤ ±0.1 mL or ±5%
● Easily fits into dual-person BSC for convenience
● Automated transfer rack for high-throughput operation accommodating 96 cryovials per rack
● Graphical guidance of the full operation via integrated UI
● Broad compatibility to external thread cryovials from multiple brands

Results

Filling volume accuracy for cell preparations: within ≤ ±0.1 mL or ±5%

Filling volume accuracy remains within ≤+0.1mL or +5% across varying fill volumes

Cell preparation filling density deviation with RSD≤10%

Post-filling viability deviation of the cell preparation is ≤5% from initial

Specification

Parameter	Specification
Dimensions (L × W × H)	Main Engine: 750 × 430 × 476.5 mm; Rack: 306.5 × 206 × 98 mm
Weight	Main Engine: 50 kg; Rack: 2.5 kg
Power Supply	AC 220 V ±10%, 50/60 Hz, 600 W
Housing Materials	ABS & SS304
Operating Environment	Designed for operation under Class A cleanroom environment
Minimum Installation Footprint	L 1,200 × W 500 × H 500 mm
Sterilization Tolerance	75% alcohol wipe-down, UV irradiation, or VHP
Pump Speed	0–300 rpm
Pump Accuracy	± 1 rpm
Rack Transfer Speed	50–100 mm/s
Rack Capacity	96 vials per rack
Compatible Cryovials	2 mL/ 4 mL/ 5 mL cryovials with screw caps and anti-rotation base
Filling Throughput	8 vials per cycle
Decapping & Recapping Throughput	16 vials per cycle
Filling Volume	0.1–5 mL
Filling Volume RSD	≤ ±0.1 mL or ±5%
Throughput	Up to 1,000 vials/h
Minimum Filling Feed Volume	≥ 50 mL

Video

3D FloTrix™ vivaFILL Cryovial Filling System

Brochures

3D FloTrix™ vivaFILL Cryovial Filling System

coming soon

Apr 11,2025

Catalogue No./ Model	Product Name	Specification
vivaFILL	3D FloTrix vivaFILL Cryovial Filling System	1 Main Engine
FILL-01-01	3D FloTrix vivaFILL Cryovial Filling Tubing Kit	1 Set, Silicone & PVC & Male Luer