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3D FloTrix™ vivaSPIN-SU Single-Use Cell Culture System

Fully automated benchtop bioreactors & single-use 3D cell culture bags, designed for 3D FloTrix™ cell culture technology, ranging from 5L to 15L.

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Details

Overview

The 3D FloTrix™ vivaSPIN-SU Single-Use Bioreactor System is a scalable, high-performance platform engineered for modern bioprocessing. Supporting expansion from 100 million to over one billion cells, it ensures consistent and reproducible outcomes across development and production batches.

Optimised with advanced fluid dynamics, the system achieves perfectly balanced nutrient and gas exchange under ultra-low shear conditions, safeguarding cellular integrity and maintaining optimal biological functionality even in high-density cultures. Its fully closed, pre-sterilised design eliminates the need for cleaning validation, significantly reducing preparation time, and operational costs while maintaining full GMP compliance.

Applications

● Advanced Therapeutic Manufacturing (stem cell therapy, immunotherapy, and exosome therapy production)
● Biopharmaceutical Production (vaccine development, antibody manufacturing, and gene therapy vector production)
● Specialised Bioprocessing Applications (oncolytic virus production and cultivated meat production)

Product Features

● Industrial-grade mixing ensures uniform nutrient distribution and and stable cell suspension across scales ranging from 100 million to billion-cell cultures.
● Ultra-low shear conditions (<10 s⁻¹) provide a gentle microenvironment for stem cells, ensuring high viability and potent therapeutic output.
● High-efficiency oxygen transfer enabled by advanced aeration supports high-density cell expansion.
● A pre-sterilised, single-use design eliminates the need for cleaning, autoclaving, or calibration, significantly reducing operational time and costs.
● Streamlined, ready-to-use operation boosts efficiency by allowing teams to focus exclusively on R&D and production, not preparation.
● A fully closed system with 5-layer film construction and ULDPE contact layer to minimise contamination risks and ensure optimal biocompatibility.
● Animal origin-free components with validated biocompatibility support product safety and regulatory alignment.
● PECALS™️ Control System integrated with smart sensors and automated controls to deliver precise, audit-ready bioprocessing.

Results

MSC Cell Production Case Study

System	Cell Type	Culture Time	Proliferation	Control Group
3D FloTrix vivaSPIN-SU™️ Cell Culture Bag 5L	MSC Cells P5	4 days	14.0-fold	14.9-fold
3D FloTrix vivaSPIN-SU™️ Cell Culture Bag 15L	MSC Cells P6	4 days	15.3-fold	14.3-fold

Specification

Parameter	Specification
Power	AC 220 V ±10%, 50/60 Hz, 1500W
Dimensions (L x W x H)	Controller: 655 x 363 x 702 mm; Extension Module: 406 x 433 x 920 mm
Weight	Controller: 36 kg; Extension Module: 31 kg
Control System	Powered by PECALS MS Control
Magnetic Drive	0.4 kW, 1.27 N.m, 0-400 rpm
Motor Accuracy	±1 rpm
Weight Accuracy	±0.1%
Volume Accuracy	±1%
Temperature Sensor	Pt100 Class AA
Temperature Control Range	2 °C to 50 °C
Operating Temperature Range	20 °C (or ambient +5 °C) to 40 °C
Temperature Control Accuracy	±0.2 °C
Gas Filtration Method	0.2 µm gas filter; Flexible configuration based on process requirements
MFC	AIR, O₂, N₂: 5-250 mL/min; CO₂: 10-500 mL/min
MFC Accuracy	1% FS
pH Sensor Accuracy	pH 6.75-7.25: ±0.05; pH 6.5-6.75 / 7.25-7.5: ±0.1
pH Control Range	6.0-8.0
pH Control Accuracy	pH 6.75-7.25: ±0.1; pH 6.5-6.75 / 7.25-7.5: ±0.15
DO Range	0%-200% air saturation
DO Sensor Accuracy	±5% air saturation
DO Control Range	0%-100% air saturation
DO Control Accuracy	±10%
Pump Model	3 × Watson Marlow 114
Pump Rotation range	0-300 rpm
Pump Rotation Accuracy	±1 rpm

Brochures

3D FloTrix™ vivaSPIN-SU Single-Use Cell Culture System

coming soon

Catalogue No./ Model	Product Name	Specification
FTVS-SU05	3D FloTrix vivaSPIN-SU Single-Use Cell Culture System 5L	1 Set (Controller x1, Extension Module x1, Culture Support Module x1)
FTVS-SU15	3D FloTrix vivaSPIN-SU Single-Use Cell Culture System 15L	1 Set (Controller x1, Extension Module x1, Culture Support Module x1)
VSKZ-SU00-01	3D FloTrix vivaSPIN-SU Single-Use Controller System	1 Unit
FTVS-SU00-00	3D FloTrix vivaSPIN-SU Extension Module	1 Unit
FTVS-SU05-01	3D FloTrix vivaSPIN-SU Culture Support Module 5L	1 Unit
FTVS-SU15-01	3D FloTrix vivaSPIN-SU Culture Support Module 15L	1 Unit
R023-05-01	3D FloTrix vivaSPIN-SU Cell Culture Bag 5L	1 Bag/Box
R023-15-01	3D FloTrix vivaSPIN-SU Cell Culture Bag 15L	1 Bag/Box