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3D FloTrix™ vivaSPIN-SU Single-Use Cell Culture System

Fully automated benchtop bioreactors & single-use 3D cell culture bags, designed for 3D FloTrix™ cell culture technology, ranging from 5L to 15L.

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Details

Overview

3D FloTrix™ vivaSPIN-SU Single-Use Bioreactor System stands as a groundbreaking innovation in modern bioprocess engineering. Purpose-built to accommodate massive expansion scales—from 100 million to over one billion cells—it delivers uncompromised performance and reproducibility across every batch. Optimized with advanced fluid dynamics, the system achieves perfectly balanced nutrient and gas exchange under ultra-low shear conditions, safeguarding cellular integrity and maintaining optimal biological functionality even in high-density cultures. Its fully closed, pre-sterilized design eliminates the need for cleaning validation, significantly reducing preparation time and operational costs while maintaining full GMP compliance.

Applications

● Advanced Therapeutic Manufacturing (stem cell therapy, immunotherapy, and exosome therapy production)
● Biopharmaceutical Production (vaccine development, antibody manufacturing, and gene therapy vector production)
● Specialized Bioprocessing Applications (oncolytic virus production and cell-cultured meat bioprocessing)

Product Features

● Industrial-grade mixing ensures uniform nutrient distribution and cell suspension across massive scales from 100 million to billion-cell cultures.
● Exceptionally low shear rates under 10s⁻¹ provide a gentle microenvironment for stem cells, ensuring high viability and potent therapeutic output.
● High-efficiency oxygen transfer is guaranteed by advanced aeration technology, supporting high-yield cell production.
● A pre-sterilized, single-use design eliminates the need for cleaning, autoclaving, or calibration, significantly reducing operational time and costs.
● Streamlined, ready-to-use operation boosts efficiency by allowing teams to focus exclusively on R&D and production, not preparation.
● A fully closed system with 5-layer film construction and ULDPE contact layer to minimize contamination risks and ensure optimal biocompatibility.
● Certified animal-free components with rigorous biocompatibility testing for uncompromised product safety and regulatory compliance.
● PECALS Control System integrated with smart sensors and automated controls to deliver precise, audit-ready bioprocessing.

Results

MSC Cell Production Case Study

System	Cell Type	Culture Time	Proliferation	Control Group
3D Flotrix® vivaSPIN-SU Cell Culture Bag 5L	MSC Cells P5	4 days	14.0-fold	14.9-fold
3D Flotrix® vivaSPIN-SU Cell Culture Bag 15L	MSC Cells P6	4 days	15.3-fold	14.3-fold

Specification

Parameter	Specification
Power	AC 220 V ±10%, 50/60 Hz, 1500W
Dimensions (L x W x H)	Controller: 655 x 363 x 702 mm; Extension Module: 406 x 433 x 920 mm
Weight	Controller: 36 kg; Extension Module: 31 kg
Control System	Powered by PECALS MS Control
Magnetic Drive	0.4 kW, 1.27 N.m, 0-400 rpm
Motor Accuracy	±1 rpm
Weight Accuracy	±0.1%
Volume Accuracy	±1%
Temperature Sensor	Pt100 Class AA
Temperature Control Range	2 °C to 50 °C
Operating Temperature Range	20 °C (or ambient +5 °C) to 40 °C
Temperature Control Accuracy	±0.2 °C
Gas Filtration Method	0.2 µm gas filter; Flexible configuration based on process requirements
MFC	AIR, O₂, N₂: 5-250 mL/min; CO₂: 10-500 mL/min
MFC Accuracy	1% FS
pH Sensor Accuracy	pH 6.75-7.25: ±0.05; pH 6.5-6.75 / 7.25-7.5: ±0.1
pH Control Range	6.0-8.0
pH Control Accuracy	pH 6.75-7.25: ±0.1; pH 6.5-6.75 / 7.25-7.5: ±0.15
DO Range	0%-200% air saturation
DO Sensor Accuracy	±5% air saturation
DO Control Range	0%-100% air saturation
DO Control Accuracy	±10%
Pump Model	3 × Watson Marlow 114
Pump Rotation range	0-300 rpm
Pump Rotation Accuracy	±1 rpm

Brochures

3D FloTrix™ vivaSPIN-SU Single-Use Cell Culture System

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Catalogue No./ Model	Product Name	Specification
FTVS-SU05	3D FloTrix™ vivaSPIN-SU Single-Use Cell Culture System 5L	1 Set (Controller x1, Extension Module x1, Culture Support Module x1)
FTVS-SU15	3D FloTrix™ vivaSPIN-SU Single-Use Cell Culture System 15L	1 Set (Controller x1, Extension Module x1, Culture Support Module x1)
VSKZ-SU00-01	3D FloTrix™ vivaSPIN-SU Single-Use Controller System	1 Unit
FTVS-SU00-00	3D FloTrix™ vivaSPIN-SU Extension Module	1 Unit
FTVS-SU05-01	3D FloTrix™ vivaSPIN-SU Culture Support Module 5L	1 Unit
FTVS-SU15-01	3D FloTrix™ vivaSPIN-SU Culture Support Module 15L	1 Unit
R023-05-01	3D FloTrix™ vivaSPIN-SU Cell Culture Bag 5L	1 Bag/Box
R023-15-01	3D FloTrix™ vivaSPIN-SU Cell Culture Bag 15L	1 Bag/Box