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3D FloTrix™ megaSPIN Single-Use Cell Culture System

A fully automated 50L single-use bioreactor designed for 3D FloTrix™ cell culture technology.

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Overview

The 3D FloTrix™ megaSPIN Single-Use Cell Culture System establishes a new paradigm in industrial bioprocessing, commanding fully automated 50L 3D cell culture capable of scaling to 100 billion cells. This integrated platform fuses uncompromising precision bioreactor controls with pharmaceutical-grade single-use technology to ensure flawless nutrient distribution and ultra-gentle processing, thereby safeguarding cellular integrity. Featuring an advanced aeration system and completely closed-system architecture, the megaSPIN eliminates costly cleaning validation while guaranteeing total regulatory compliance for next-generation therapeutic manufacturing.

Applications

● Advanced Therapeutic Manufacturing – Large-scale production of stem cell therapies, immunotherapies, and exosome-based therapeutics.
● Biopharmaceutical Manufacturing – Industrial-scale vaccine development, antibody production, and gene therapy vector manufacturing.
● Specialized Bioprocessing Applications – High-volume oncolytic virus production and scalable cell-cultured meat bioprocessing.

Product Features

● Industrial-grade mixing technology ensures flawless nutrient distribution across scales from billion to hundred-billion cell cultures.
● Ultra-low shear rates (<10s⁻¹) maintain stem cell potency and viability through gentle hydrodynamic processing.
● Advanced aeration systems deliver superior oxygen transfer efficiency for maximum cell yield and productivity.
● Pre-sterilized single-use architecture eliminates cleaning, autoclaving and calibration requirements.
● Streamlined ready-to-use operation enables focused R&D and production without preparatory burdens.
● Fully closed-system design with 5-layer film and ULDPE contact layer ensures maximum contamination control.
● Certified animal-free components with rigorous biocompatibility testing guarantee regulatory compliance.
● Precision control program integrated with smart sensors and automated controls to deliver precise, audit-ready bioprocessing.

Results

MSC Cell Production Case Study

Reactor	Cell Type	Culture Time	Proliferation Fold
SU-15L	UCMSC	96h	13.53
mega-50L		120h	16.15
VS-5L		96h	11.67
VS-15L		96h	12.37

Specification

Parameter	Specification
Power	AC 220 V ±10%, 50/60 Hz, 1
Dimensions (L x W x H)	Controller: 600 x 1620 x 800 mm; Extension Module: Φ 460×1820mm
Weight	Controller: 120 kg; Extension Module: 120 kg
Control System	Powered by PECALS-SU Control System
Magnetic Drive	0.4 kW, 1.27 N.m, 0-400 rpm
Motor Accuracy	±1 rpm
Weight Accuracy	±0.1%
Volume Accuracy	±1%
Temperature Sensor	Pt100 Class AA
Temperature Control Range	2 °C to 50 °C
Operating Temperature Range	20 °C (or ambient +5 °C) to 40 °C
Temperature Control Accuracy	±0.2 °C
Gas Filtration Method	0.2 µm gas filter; Flexible configuration based on process requirements
MFC	AIR, O₂, N₂: 5-250 mL/min; CO₂: 10-500 mL/min
MFC Accuracy	1% FS
pH Sensor Accuracy	pH 6.75-7.25: ±0.05; pH 6.5-6.75 / 7.25-7.5: ±0.1
pH Control Range	6.0-8.0
pH Control Accuracy	pH 6.75-7.25: ±0.1; pH 6.5-6.75 / 7.25-7.5: ±0.15
DO Range	0%-200% air saturation
DO Sensor Accuracy	±5% air saturation
DO Control Range	0%-100% air saturation
DO Control Accuracy	± 10%
Pump Model	2 × Watson Marlow 114, 2 × Watson Marlow 314
Pump Rotation range	≤400 rpm
Pump Rotation Accuracy	±1 rpm

Brochures

3D FloTrix™ megaSPIN Single-Use Cell Culture System

coming soon

Apr 11,2025

Catalogue No./ Model	Product Name	Specification
FTMS50	3D FloTrix™ megaSPIN Single-Use Cell Culture System 50L	1 Set (Controller x1, Culture Support Module x1, TCU x1)
R022-50-01	3D FloTrix™ megaSPIN Cell Culture Bag 50L	1 Bag/Box