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3D TableTrix™ Microcarriers G02

Bovine gelatin microcarriers for HEK293T cells.

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Overview

3D TableTrix™ Microcarrier G02 establishes a precedent in bioprocessing with its advanced bovine gelatin platform, featuring precision-engineered microcarriers of exceptional porosity and structural uniformity. The pharmaceutical-grade system provides a superior biomimetic environment for high-value cell cultivation and viral production in 293T and Vero cell lines. Incorporating proprietary gentle degradation technology and full regulatory certification, the ready-to-use platform guarantees optimal cell viability and harvest performance. Seamlessly integrated with the 3D FloTrix™ dynamic culture platform, TableTrix™ G02 supports efficient, scalable, and industrialised biomanufacturing workflows.

Applications

● Gene Therapy Research & Manufacturing
● Lentiviral Vector Production
● Adeno-Associated Virus (AAV) Production
● Oncolytic Virus Production

Product Features

● Sterile, closed-system ready, enabling direct bioreactor integration and fully closed-process cultivation.

● 3D biomimetic structure provides a natural growth environment for superior cell attachment.
● High porosity matrix with specific surface area up to 9000 cm²/g.
● Fully degradable offering higher cell recovery than paper carriers and supporting continuous scale-up culture.
● Elastic porous design with 3D biomimetic architecture that reduces shear stress in stirred-tank reactors, protecting host cells and minimizing residual host cell proteins.
● Broad cell line compatibility with various adherent cell lines including 293T and Vero, ideal for large-scale viral vector production (lentivirus, adenovirus, AAV).

Results

Established process parameters from conventional 2D culture systems can be readily adapted to 3D microcarrier-based workflows, enabling seamless process transfer and scale-up for large-scale viral vector manufacturing.

A stepwise scale-up strategy from N-1 to N production phase demonstrates efficient and reproducible cell expansion in stainless steel bioreactor systems.

Cell density increases progressively across phases, achieving a peak density of approximately 6.6 × 10⁶ cells/mL, while maintaining stable growth kinetics throughout the scale-up process.

Enhanced Viral Titer (Virus A) The 3D TableTrix™ microcarrier platform consistently delivers higher viral titers compared to conventional 2D culture, achieving approximately ~7.0–7.3 log CCID₅₀/mL, versus ~5.1 log CCID₅₀/mL in 2D systems, demonstrating a substantial improvement in production efficiency.

Stable and reproducible output viral production remains stable across the culture duration, with minimal fluctuation in titer, indicating robust process consistency under dynamic culture conditions.

Continuous multi-stage scale-up and subculture of Vero cells can be effectively achieved using the 3D TableTrix™ microcarrier platform, reaching peak cell densities of up to 1 × 10⁷ cells/mL in cell culture systems.

Viral titer and overall production efficiency from cells cultured on 3D TableTrix™ microcarriers are significantly enhanced compared to conventional 2D planar cultures and traditional spherical microcarrier systems, demonstrating clear advantages in both productivity and scalability.

Specification

Parameter	Specification
Structure & Morphology	3D porous spherical microcarriers, porosity > 90%
Raw Material	Gelatin
Degradability	Fully degradable
Packaging	20mg/tablet, 1g/bottle; 10g/bottle
Model	G02-200; G02-10-10g
Sterility	Sterile
Carrier Particle Size (dry powder)	120-180 μm
Pore Size Range (swollen)	30-50 μm
Effective Growth Area	9000 cm²/g
Suitable Cell Types	293T, Vero, and other cells
Usage	Ready-to-use
Cell Harvesting	Microcarrier-degradable process

Technical Data Sheet

Microcarrier	Material	Structure	Dissolvable	Bead Size (μm)	Surface Area （cm²/g）	Bead Number (particles/mg)	Pore Size (μm)	Packaging	Application Field
W01	Porcine Gelatin	Macroporous sphere	Yes	40-330	8300	4200	0-50	Sterile Tablets \| Sterile Powder in Closed System	Mesenchymal stromal cells and exosomes
V01	Bovine Gelatin	Macroporous sphere	Yes	140-480	7500	2200	30-50	Non-sterile power	Human and animal vaccines, i.e. Vero, MDCK, MRC5
G02	Bovine Gelatin	Macroporous sphere	Yes	110-380	5900	2400	30-50	Sterile Tablets \| Sterile Powder in Closed System	Lenti-virus, Adeno-associatedvirus, oncolytic virus, i.e. 293T cells
CW01	Recombinant Collagen	Macroporous sphere	Yes	120-300	6300	4300	20-40	Sterile Tablets \| Sterile Powder in Closed System	Mesenchymal stromal cells and exosomes

3D FloTrix™ microSPIN & miniSPIN FLEX2025.4.25

Centimeter-Scale Self-Assembling Tendon Organoids Drive Tissue Regeneration

Fang, T., Zhang, H., Xie, Y., Li, X., Liu, X., Wang, Z., Xue, Y., Xia, X., Wang, Z., Lei, T., Lin, R., Shen, W., Wu, B., Chen, Y., Du, Y., Chen, X., & Yin, Z. (2025). Centimeter‐Scale Self‐Assembling tendon organoids drive tissue regeneration. Advanced Science, 12(43), e09453.

Aug 29,2025

Catalogue No./ Model	Product Name	Specification
G02-200	3D TableTrix Microsphere G02 (Tablets)	2g (20mg/tablet x 50tablets/box x 2 boxes)
G02-10-10g	3D TableTrix Microsphere G02 (Powder)	10g/Bottle