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RMZ112 Starter Kit

Xeno-free, serum-free cell culture medium for isolation, expansion and large-scale production of mesenchymal stem cells.

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Overview

RMZ112 Sampling Kit provides a comprehensive entry point into advanced MSC biomanufacturing through an integrated system comprising pharmaceutical-grade serum-free medium and a precision enzymatic digest reagent.This carefully designed kit enables thorough evaluation of complete 3D bioprocessing workflows, featuring regulatory-supported culture medium for optimal cell expansion alongside a specialised enzymatic formulation for gentle microcarrier dissolution. Together, these components demonstrate the seamless integration of enhanced cell cultivation and refined harvesting methods, providing essential operational insights for scalable therapeutic manufacturing while maintaining stringent quality standards.

Applications

● Industrial-scale expansion of multiple mesenchymal stem cell variants
● Advanced therapeutic medicinal product (ATMP) development
● cGMP-compliant industrial bioprocessing

Product Features

● High specification formulation that is serum-free, animal origin-free and phenol red-free and ensures batch-to-batch variation.
● Ready-to-use convenience requiring no additional growth factors, coating, or surface treatment.
● Superior performance supporting large-scale expansion of various mesenchymal stem cell types.
● Extended culture capability enabling stable, continuous passaging for over 14 days.
● Dual culture flexibility, compatible with both 2D and 3D culture modalities.
● Versatile applications supporting both primary cell isolation and subsequent passaging.
● Reliable supported by stable production and ready-to-ship availability.
● Proven regulatory support through extensive collaboration with pharmaceutical partners to accelerate drug approval.
● Quality assurance ensured through a GMP-compliant production environment and robust quality management systems.

Results

Cumulative cell numbers harvested in the scale-up process

Cumulative cell expansion fold in the scale-up process

Cell viability at each stage of scale-up

**Cumulative population doublings (PDL) in the scale-up process**

Caption (suggested):
Human mesenchymal stem cells (MSCs) cultured using the 3D FloTrix™️ microcarrier-based dynamic culture system demonstrated robust scalability from 1 L to 15 L bioreactor volumes. Total cell yield increased proportionally with scale while maintaining cell viability above 95% and stable population doubling levels, confirming the platform’s suitability for large-scale therapeutic cell manufacturing.

Comparison of UCMSC Viability Across Different Culture Media

Capitalise: Medium A, B, C