3D RecomTrix® Recombinant Collagen Microcarrier retains the major characteristics of the CytoNiche Microcarrier, with the only difference being that it is composed of non-animal sourced recombinant collagen protein.

The 3D TableTrix® microcarrier family is a series of independently developed products, consisting of tens of thousands of elastic three-dimensional porous microcarriers with a porosity >90%. The particle size is controllable within the range of 50-500 μm, with a large specific surface area. The uniformity is ≤100μm. It incorporates specific degradation technology, allowing gentle cell harvesting and forming a truly 3D biomimetic culture. The 3D TableTrix® microcarrier series (W series, V series, G series) complies with GMP-level production, suitable for adherent cell cultivation, and enables the harvesting of cells, viruses, and cell products. It has obtained two Chinese CDE (Center for Drug Evaluation) qualifications for pharmaceutical excipients (Record numbers: F20200000496; F20210000003), and three U.S. FDA qualifications for drug substances and pharmaceutical excipients (DMF II & IV types, MF II record numbers: 037798 & 035481, 29721).

The 3D FloTrix® vivaFILL Cryovial Filling System addresses key challenges in the filling process of cells, including large filling volumes, complex intra-batch quality control, and high costs. This system enhances the accuracy, consistency, stability, and repeatability of cell/strain banks or final products, ensuring compliance with quality control standards for enterprises engaged in cell production.

Revolutionize your cell therapy production with the 3D FloTrix® vivaPACK Cryobag Filling System! This cutting-edge, high-throughput automated equipment is tailor-made for the preparation and production of cell therapy products. Paired with closed & sterile disposable tubing kit, it enables seamless, fully closed formulation filling processes, handling over a hundred bags with ease.

3D FloTrix® vivaSPIN Bioreactor is a closed, automated, and scalable stirred bioreactor developed by CytoNiche to achieve high-quality large-scale cultivation of 3D cells. Based on the core technology products, the 3D TableTrix® microcarrier, and the 3D FloTrix® dynamic cultivation process, CytoNiche has taken into full consideration factors such as fluid dynamics and process control parameters. The optimization design covers various aspects, including tank structure, pipe fittings, and control procedures.

By combining an electrically driven magnetic agitation device with the innovative 3D FloTrix® 6-Well Plate with Impellers, the 3D FloTrix® microSPIN Multiplex System facilitates simultaneous exploration and validation of various agitation process conditions in a miniaturized setting. This versatile micro system caters to a wide array of applications, including scientific research, drug development and others.

3D FloTrix® miniSPIN FLEX System is an electrically driven magnetic stirring device designed specifically for the suspension culture of adherent cells. When combined with disposable reaction bottles, it facilitates scientific research, R&D exploration, and small-scale process validation. The device utilizes an ultralow-speed stirring mode to enhance the fluidity of the culture medium around the cells. It is suitable for the suspen-sion culture of adherent cells and microcarriers, single-cell suspension culture, strain and cell line screening, cell proliferation culture, and related process optimization.

3D FloTrix® vivaPREP utilizes the principle of gradient centrifugation, coupled with a disposable closed system, to complete various cell processing steps, including cell resuscitation, washing, and concentration. This system is recommended for processing ≤ 1 billion (mesenchymal stem) cells.

3D FloTrix® vivaPREP PLUS is a fully automated and closed cell processing system specifically designed for cell therapy. Utilizing the principle of continuous flow centrifugation, together with single-use processing kit, it is suitable to concentrate and wash cells at a large scale. This system is recommended for processing 10 billion (mesenchymal stem) cells.

The 3D FloTrix® vivaEXO Exosome Harvesting System is an automated solution for large-scale concentration and enrichment of exosomes using multi-stage separation technology. Designed to meet modern medical and hygiene standards, this system's main unit and disposable consumable kits adhere to GMP requirements. It enables real-time parameter recording and precise control, all presented through a user-friendly human-computer interaction interface.

Introducing the 3D FloTrix® vivaROCK Bioreactor System: Designed for high-quality scalable cultivation of cells in disposable culture bags. This system provides a gentle, low-shear, high-oxygen cell culture microenvironment, suitable for suspension cell culture, or couple with our 3D TableTrix® Microcarriers to comprehensively enhance quality and yield of adherent cells.

The 3D FloTrix® Mesenchymal Stem Cell Culture Medium is a serum-free and ani-mal-free medium for the proliferation and maintenance of mesenchymal stem cells. With high quality, cost-effectiveness, and safety assurance, it can help our pharmaceutical clients successfully go through drug application processes and expedite the develop-ment of biopharmaceuticals.

Exosome is a type of extracellular vesicle with a particle size of 30-150 nm. At present, it is mainly used in disease treatment, drug carrier, disease diagnosis, etc.